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In the early years of anabolic steroid development, there was no standardized test method for different steroids or the method of measuring their strength(or lack thereof). Steroid research and development was also largely based on personal observations and was largely experimental. In the mid 1980s, there was a growing realization that in the late 1970s and early 1980s, when the testing methods were developing, a lot of steroids, including testosterone, were being tested in laboratory animal models using a variety of compounds to simulate the effect that anabolic steroids had on humans. Many steroid users believed that they were getting an unfair amount of test compounds. In late October 1984, during an effort to test more controlled amounts of steroids in women for a study that would determine the relationship between anabolic androgens and bone mass, the National Toxicology Program (NTP) administered the "WADA-sponsored Female Anabolic Steroid/Testosterone Study."5 The NTP report was heavily criticized for its methodology and conclusions. The report described women as using anabolic steroids for a wide variety of muscle conditions, most notably to increase muscle growth. However, the report did not measure the effect of anabolic steroids on women's muscle density, muscular endurance, metabolic responses to exercise, muscular strength, and other muscle qualities measured in anabolic steroids administration.5,6 Most research on estrogen is based on animal models, a method that has been criticized for its limited study and reproducibility as well as its failure to establish the role of the estrogen in promoting weight training and bodybuilding gains (reviewed by Johnson and Johnson in 2006).7 There is also evidence that estrogen does not promote muscle hypertrophy or prevent losses.8 The study described in the WADA-sponsored study was an extension of the NTP "male-centric approach to steroid testing" in which the study was intended to determine the efficacy of administering anabolic steroids to women on an as needed basis.7 When the study started, researchers and medical doctors knew little about the hormonal effects of anabolic steroids. One of the first studies was conducted by Drs. T.J. Smith-Hicks and R.G. Brown in the early 80s.9 Brown noted that anabolic steroids increase the muscle protein synthesis capacity of testosterone, the steroid that was most commonly administered to humans to stimulate muscle growth, and the effects of testosterone on muscle growth were not as well understood. Other investigators had noted that testosterone, like anabolic steroids, causes the levels and synthesis rates of muscle proteins to increase.9 They also noted the importance of increased muscle protein synthesis on increasing the rates of muscle growth in a variety of animal models. Similar articles: